Article
Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994
Sweeney H L, Yang Z, Zhi G, Stull J T, Trybus K M
Abstract excerpt
Phosphorylation of the myosin regulatory light chains (RLCs) activates contraction in smooth muscle and modulates force production in striated muscle. RLC phosphorylation changes the net charge in a critical region of the N terminus and thereby may alter interactions between the RLC and myosin heavy chain. A series of N-terminal charge mutations in the human smooth muscle RLC has been engineered, and the mutants...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.