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Article

A molecular mechanism for autoinhibition of myosin light chain kinases.

The Journal of biological chemistry - 15 Dec 1993

Gallagher P J, Herring B P, Trafny A, Sowadski J, Stull J T

Abstract excerpt

It is postulated that basic residues within the inhibitory region of myosin light chain kinase (MLCK) bind acidic residues within the catalytic core to maintain the kinase in an inactive form. In this study, we identified residues within the catalytic cores of the skeletal and smooth muscle MLCKs that may bind basic residues in inhibitory region. Acidic residues within the catalytic core of the rabbit skeletal...

Topics

Animals
Catalysis
Cattle
Cell Line
Models, Molecular
Muscle, Smooth
Muscles
Mutation
Myosin-Light-Chain Kinase
Rabbits

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8253787
PMCID: PMC2836759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8253787-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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