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Article

Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains.

Journal of structural biology - 1 Jan 1998

Levine R J, Yang Z, Epstein N D, Fananapazir L, Stull J T, Sweeney H L

Abstract excerpt

The ordered array of myosin heads, characteristic of relaxed striated muscle thick filaments, is reversibly disordered by phosphorylating myosin regulatory light chains, decreasing temperature and/or ionic strength, increasing pH, and depleting nucleotide. In the case of light chain phosphorylation, disorder, most likely due to a change in charge affecting the light chain amino-terminus, reflects increased myosin...

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Identifiers

PMID: 9724616
DOI: 10.1006/jsbi.1998.3980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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