Article
Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains.
Journal of structural biology - 1 Jan 1998
Levine R J, Yang Z, Epstein N D, Fananapazir L, Stull J T, Sweeney H L
Abstract excerpt
The ordered array of myosin heads, characteristic of relaxed striated muscle thick filaments, is reversibly disordered by phosphorylating myosin regulatory light chains, decreasing temperature and/or ionic strength, increasing pH, and depleting nucleotide. In the case of light chain phosphorylati...
Topics
- Actin Cytoskeleton
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Cardiomyopathy, Hypertrophic
- Cell Membrane Permeability
- Humans
- Microscopy, Electron
- Molecular Sequence Data
- Muscle Fibers, Skeletal
- Muscle Fibers, Slow-Twitch
- Muscle, Skeletal
- Mutation
- Myosin Light Chains
- Phosphorylation
- Rabbits
- Structure-Activity Relationship