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Article

Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model.

Molecular vision - 1 Jan 2015

Sahu Bhubanananda, Chavali Venkata R M, Alapati Akhila, Suk John, Bartsch Dirk-Uwe, Jablonski Monica M, Ayyagari Radha

Abstract excerpt

PURPOSE: A spontaneous frameshift mutation, c.3481delC, in the Crb1 gene is the underlying cause of dysplasia and retinal degeneration in rd8 mice. The rd8 mutation is found in C57BL/6N but not in C57BL/6J mouse sub-strains. The development of ocular pathology in single knockout Ccl2-/-, Cx3cr1-/- and in double knockout Ccl2-/-, Cx3cr1-/- mice raised on a C57BL/6 background has been reported to depend on the...

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Identifiers

PMID: 25814825
PMCID: PMC4360165

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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