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Article

The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.

Human molecular genetics - 1 Jan 2015

Luhmann Ulrich F O, Carvalho Livia S, Holthaus Sophia-Martha Kleine, Cowing Jill A, Greenaway Simon, Chu Colin J, Herrmann Philipp, Smith Alexander J, Munro Peter M G, Potter Paul, Bainbridge James W B, Ali Robin R

Abstract excerpt

Understanding phenotype-genotype correlations in retinal degeneration is a major challenge. Mutations in CRB1 lead to a spectrum of autosomal recessive retinal dystrophies with variable phenotypes suggesting the influence of modifying factors. To establish the contribution of the genetic background to phenotypic variability associated with the Crb1(rd8/rd8) mutation, we compared the retinal pathology of...

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Share to Chromosomes, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Nerve Tissue Proteins

Share to Photoreceptor Cells, Vertebrate

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Share to Retinal Diseases

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Source

Open in PubMed Open full text

Identifiers

PMID: 25147295
DOI: 10.1093/hmg/ddu424
PMCID: PMC4262495

Genes

CRB1

Provenance

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