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Article

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.

Brain : a journal of neurology - 1 Jun 2012

Petratos Steven, Ozturk Ezgi, Azari Michael F, Kenny Rachel, Lee Jae Young, Magee Kylie A, Harvey Alan R, McDonald Courtney, Taghian Kasra, Moussa Leon, Mun Aui Pei, Siatskas Christopher, Litwak Sara, Fehlings Michael G, Strittmatter Stephen M, Bernard Claude C A

Abstract excerpt

Multiple sclerosis involves demyelination and axonal degeneration of the central nervous system. The molecular mechanisms of axonal degeneration are relatively unexplored in both multiple sclerosis and its mouse model, experimental autoimmune encephalomyelitis. We previously reported that targeting the axonal growth inhibitor, Nogo-A, may protect against neurodegeneration in experimental autoimmune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Source

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Identifiers

PMID: 22544872
DOI: 10.1093/brain/aws100
PMCID: PMC3589918

Genes

MOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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