Article
Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.
The Journal of biological chemistry - 13 Jun 2008
Williams Gareth, Wood Andrew, Williams Emma-Jane, Gao Ying, Mercado Mary L, Katz Alan, Joseph-McCarthy Diane, Bates Brian, Ling Huai-Ping, Aulabaugh Ann, Zaccardi Joe, Xie Yuhong, Pangalos Menelas N, Walsh Frank S, Doherty Patrick
Abstract excerpt
Gangliosides are key players in neuronal inhibition, with antibody-mediated clustering of gangliosides blocking neurite outgrowth in cultures and axonal regeneration post injury. In this study we show that the ganglioside GT1b can form a complex with the Nogo-66 receptor NgR1. The interaction is shown by analytical ultracentrifugation sedimentation and is mediated by the sialic acid moiety on GT1b, with mutations...
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