Article
Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo.
Neuron - 26 Apr 2012
Wu Wei, Ahlsen Goran, Baker David, Shapiro Lawrence, Zipursky S Lawrence
Abstract excerpt
Dscam1 potentially encodes 19,008 ectodomains of a cell recognition molecule of the immunoglobulin (Ig) superfamily through alternative splicing. Each ectodomain, comprising a unique combination of three variable (Ig) domains, exhibits isoform-specific homophilic binding in vitro. Although we have proposed that the ability of Dscam1 isoforms to distinguish between one another is crucial for neural circuit...
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