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Somatic and Germline Diversification of a Putative Immunoreceptor within One Phylum: Dscam in Arthropods.

Results and problems in cell differentiation - 1 Jan 2015

Brites Daniela, Du Pasquier Louis

Abstract excerpt

Arthropod Dscam, the homologue of the human Down Syndrome cell adhesion molecule, is a receptor used by the nervous and immune systems. Unlike in vertebrates, evolutionary pressure has selected and maintained a vast Dscam diversity of isoforms, known to specifying neuronal identity during the nervous system differentiation. This chapter examines the different modes of Dscam diversification in the context of...

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PMID: 26537380
DOI: 10.1007/978-3-319-20819-0_6

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