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Dscam homophilic specificity is generated by high order <i>cis</i> -multimers coupled with <i>trans</i> self-binding of variable Ig1 in Chelicerata

2019-12-16

Abstract excerpt

By alternative splicing, Drosophila Down syndrome cell adhesion molecule ( Dscam1 ) encodes tens of thousands of proteins required for establishing neural circuits, while Chelicerata encodes a family of ∼ 100 shortened Dscam (sDscam) isoforms via alternative promoters. We report that Dscam isoforms interact promiscuously in cis to generate a vast repertoire of combinatorial homophilic recognition specificities...

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Identifiers and source

Literature Corpus work
4209a5e7-6d0b-5533-b9ca-0acd54ae19e2
DOI
10.1101/2019.12.15.877159
Open publication

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Dscam homophilic specificity is generated by high order <i>cis</i> -multimers coupled with <i>trans</i> self-binding of variable Ig1 in ChelicerataDOI 10.1101/2019.12.15.877159
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