Article
Bias in association studies of systemic lupus erythematosus susceptibility due to geographical variation in the frequency of a programmed cell death 1 polymorphism across Europe.
Genes and immunity - 1 Mar 2007
Ferreiros-Vidal I, D'Alfonso S, Papasteriades C, Skopouli F N, Marchini M, Scorza R, Migliaresi S, Sebastiani G D, Endreffy E, Mavromati M, Kappou-Rigatou I, Ruzickova S, Dostal C, Schmidt R E, Witte T, Gomez-Reino J J, Gonzalez A
Abstract excerpt
We obtained eight collections of DNA samples from ethnically matched systemic lupus erythematosus (SLE) patients and controls from five European countries totaling 783 patients and 1210 controls. A highly significant cline in the frequency of the PD1.3 A allele was found among controls but not among SLE patients. The frequency of the PD1.3 A allele increased from the Northeast to the Southwest of Europe. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.