Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

doi:10.1186/ar4585

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Article

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

Arthritis research & therapy - 19 Jun 2014

Alonso-Perez Elisa, Suarez-Gestal Marian, Calaza Manuel, Blanco Francisco J, Suarez Ana, Santos Maria Jose, Papasteriades Chryssa, Carreira Patricia, Pullmann Rudolf, Ordi-Ros Josep, Marchini Maurizio, Skopouli Fotini N, Bijl Marc, Barrizone Nadia, Sebastiani Gian Domenico, Migliaresi Sergio, Witte Torsten, Lauwerys Bernard R, Kovacs Attila, Ruzickova Sarka, Gomez-Reino Juan J, Gonzalez Antonio

Abstract excerpt

INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. METHODS: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed...

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PMID: 24946689
DOI: 10.1186/ar4585
PMCID: PMC4095681

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