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Article

Cocaine self-administration behaviors in ClockΔ19 mice.

Psychopharmacology - 1 Sept 2012

Ozburn Angela Renee, Larson Erin Beth, Self David W, McClung Colleen A

Abstract excerpt

RATIONALE: A key role has been identified for the circadian locomotor output cycles kaput (Clock) gene in the regulation of drug reward. Mice bearing a dominant negative mutation in the Clock gene (ClockΔ19 mice) exhibit increased cocaine-induced conditioned place preference, reduced anxiety- and depression-like behavior, increased sensitivity to intracranial self-stimulation, and increased dopaminergic cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22535308
DOI: 10.1007/s00213-012-2704-2
PMCID: PMC3670183

Genes

CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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