Article
Regulation of dopaminergic transmission and cocaine reward by the Clock gene.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005
McClung Colleen A, Sidiropoulou Kyriaki, Vitaterna Martha, Takahashi Joseph S, White Francis J, Cooper Donald C, Nestler Eric J
Abstract excerpt
Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such interactions remain unknown. Here we establish a role for the Clock gene in regulating the brain's reward circuit. Mice lacking a functional Clock gene display an increase in cocaine reward and in the excitability of dopamine neurons in the midbrain ventral tegmental area, a key brain reward region. These...
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