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Article

Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Sept 2005

Thomsen Morgane, Woldbye David P D, Wörtwein Gitta, Fink-Jensen Anders, Wess Jürgen, Caine S Barak

Abstract excerpt

The reinforcing effects of cocaine have been related to increased extracellular concentrations of dopamine in the ventral striatum. Several studies suggest that M5 muscarinic receptors facilitate striatal dopamine release. We tested the hypothesis that the reinforcing effects of cocaine are decreased in M5 receptor-deficient mice using chronic intravenous cocaine self-administration in extensively backcrossed...

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Identifiers

PMID: 16148222
DOI: 10.1523/JNEUROSCI.2077-05.2005
PMCID: PMC6725551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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