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Article

A mutation in CLOCK leads to altered dopamine receptor function.

Journal of neurochemistry - 1 Oct 2012

Spencer Sade, Torres-Altoro Melissa I, Falcon Edgardo, Arey Rachel, Marvin Marian, Goldberg Matthew, Bibb James A, McClung Colleen A

Abstract excerpt

Mice with a mutation in the Clock gene (ClockΔ19) have a number of behavioral phenotypes that suggest alterations in dopaminergic transmission. These include hyperactivity, increased exploratory behavior, and increased reward value for drugs of abuse. However, the complex changes in dopaminergic transmission that underlie the behavioral abnormalities in these mice remain unclear. Here we find that a loss of CLOCK...

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Identifiers

PMID: 22757753
DOI: 10.1111/j.1471-4159.2012.07857.x
PMCID: PMC3438377

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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