Article
Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats.
Nature communications - 11 Jun 2026
Lara Montana Kay, Carrette Lieselot L G, Sanches Thiago Missfeldt, Polesskaya Oksana, Avelar Alicia, Beeson Angela, Beldjoud Hassiba, Boomhower Brent, Brennan Molly, Chen Denghui, Cheng Riyan, China Lindsey, Chitre Apurva S, Conlisk Dana Elizabeth, Fannon McKenzie, Johnson Benjamin B, Keung Elaine, Kimbrough Adam, Kononoff Jenni, Martinez Angelica Renee, Maturin Lisa, Nguyen Khai-Minh, Morgan Alex, Mosquera Joseph, Othman Dyar, Plasil Sonja L, Ramborger Jarryd, Schweitzer Paul, Sedighim Sharona, Seshie Osborne, Shankar Kokila, Sichel Benjamin, Simpson Sierra, Smith Lauren Cassandra, Sneddon Elizabeth A, Tieu Lani, Velarde Nathan, Zahedi Selene, Woods Leah C Solberg, Kallupi Marsida, de Guglielmo Giordano, Palmer Abraham A, George Olivier
Abstract excerpt
Cocaine use disorder (CUD) is a major public health crisis. The specific genes mediating CUD remain largely unknown. We conducted a genome-wide association study (GWAS) using outbred N/NIH Heterogeneous Stock (HS; n = 836, female = 415, male = 421) rats. We examined CUD-related phenotypes including acquisition of self-administration, escalation of intake, and compulsive-like responding. These traits were...
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