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Article

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure.

Journal of the National Cancer Institute - 16 May 2012

Munafò Marcus R, Timofeeva Maria N, Morris Richard W, Prieto-Merino David, Sattar Naveed, Brennan Paul, Johnstone Elaine C, Relton Caroline, Johnson Paul C D, Walther Donna, Whincup Peter H, Casas Juan P, Uhl George R, Vineis Paolo, Padmanabhan Sandosh, Jefferis Barbara J, Amuzu Antoinette, Riboli Elio, Upton Mark N, Aveyard Paul, Ebrahim Shah, Hingorani Aroon D, Watt Graham, Palmer Tom M, Timpson Nicholas J, Davey Smith George

Abstract excerpt

BACKGROUND: Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco...

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Identifiers

PMID: 22534784
DOI: 10.1093/jnci/djs191
PMCID: PMC3352832

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