Article
Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals.
International journal of epidemiology - 1 Apr 2010
Lips Esther H, Gaborieau Valerie, McKay James D, Chabrier Amelie, Hung Rayjean J, Boffetta Paolo, Hashibe Mia, Zaridze David, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Field John K, Liloglou Triantafillos, Xinarianos George, McLaughlin John, Liu Geoffrey, Skorpen Frank, Elvestad Maiken Bratt, Hveem Kristian, Vatten Lars, Study Epic, Benhamou Simone, Lagiou Pagona, Holcátová Ivana, Merletti Franco, Kjaerheim Kristina, Agudo Antonio, Castellsagué Xavier, Macfarlane Tatiana V, Barzan Luigi, Canova Cristina, Lowry Ray, Conway David I, Znaor Ariana, Healy Claire, Curado Maria Paula, Koifman Sergio, Eluf-Neto Jose, Matos Elena, Menezes Ana, Fernandez Leticia, Metspalu Andres, Heath Simon, Lathrop Mark, Brennan Paul
Abstract excerpt
BACKGROUND: Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct association, or whether the 15q variant is simply a proxy for increased exposure to tobacco carcinogens. METHODS: We performed a detailed analysis of one 15q single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and cancer risk in a...
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