Article
Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2011
Timofeeva Maria N, McKay James D, Smith George Davey, Johansson Mattias, Byrnes Graham B, Chabrier Amélie, Relton Caroline, Ueland Per Magne, Vollset Stein Emil, Midttun Øivind, Nygård Ottar, Slimani Nadia, Romieu Isabelle, Clavel-Chapelon Françoise, Boutron-Ruault Marie-Christine, Fagherazzi Guy, Kaaks Rudolf, Teucher Birgit, Boeing Heiner, Weikert Cornelia, Bueno-de-Mesquita H Bas, van Gils Carla, Peeters Petra H M, Agudo Antonio, Barricarte Aurelio, Huerta Jose-Maria, Rodríguez Laudina, Sánchez Maria-José, Larrañaga Nerea, Khaw Kay-Tee, Wareham Nick, Allen Naomi E, Travis Ruth C, Gallo Valentina, Norat Teresa, Krogh Vittorio, Masala Giovanna, Panico Salvatore, Sacerdote Carlotta, Tumino Rosario, Trichopoulou Antonia, Lagiou Pagona, Trichopoulos Dimitrios, Rasmuson Torgny, Hallmans Göran, Riboli Elio, Vineis Paolo, Brennan Paul
Abstract excerpt
BACKGROUNDS: Multiple polymorphisms affecting smoking behavior have been identified through genome-wide association studies. Circulating levels of the nicotine metabolite cotinine is a marker of recent smoking exposure. Hence, genetic variants influencing smoking behavior are expected to be associated with cotinine levels. METHODS: We conducted an analysis in a lung cancer case-control study nested within the...
Read the complete abstract on PubMed