Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Base Pairing between Hepatitis C Virus RNA and MicroRNA 122 3′ of Its Seed Sequence Is Essential for Genome Stabilization and Production of Infectious Virus

26 Apr 2012

Abstract excerpt

MicroRNA 122 (miR-122) facilitates hepatitis C virus (HCV) replication by recruiting an RNA-induced silencing complex (RISC)-like complex containing argonaute 2 (Ago2) to the 5' end of the HCV genome, thereby stabilizing the viral RNA. This requires base pairing between the miR-122 "seed sequence" (nucleotides [nt] 2 to 8) and two sequences near the 5' end of the HCV RNA: S1 (nt 22 to 28) and S2 (nt 38 to 43)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to MicroRNA in disease regulation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22532678
DOI: 10.1128/jvi.00513-12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Base Pairing between Hepatitis C Virus RNA and MicroRNA 122 3′ of Its Seed Sequence Is Essential for Genome Stabilization and Production of Infectious VirusPMID 22532678Read ↗

miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5' UTR RNA to stabilize and promote viral RNA accumulation.Semantic proximity Read ↗

Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3′ variantsSemantic proximity Read ↗

Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122Semantic proximity Read ↗

Impact of a Patient-Derived Hepatitis C Viral RNA Genome with a Mutated MicroRNA Binding SiteSemantic proximity Read ↗

Positive Regulation of Hepatitis E Virus Replication by MicroRNA-122Semantic proximity Read ↗

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry siteSemantic proximity Read ↗

Various miRNAs compensate the role of miR-122 on HCV replicationSemantic proximity Read ↗

MicroRNA-122 Regulation of HCV Infections: Insights from Studies of miR-122-Independent ReplicationSemantic proximity Read ↗

MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.Semantic proximity Read ↗

miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure.Semantic proximity Read ↗

Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.Semantic proximity Read ↗

Human Ago2 Is Required for Efficient MicroRNA 122 Regulation of Hepatitis C Virus RNA Accumulation and TranslationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.