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Article

Various miRNAs compensate the role of miR-122 on HCV replication

23 Jun 2020

Abstract excerpt

One of the determinants for tissue tropism of hepatitis C virus (HCV) is miR-122, a liver-specific microRNA. Recently, it has been reported that interaction of miR-122 to HCV RNA induces a conformational change of the 5'UTR internal ribosome entry site (IRES) structure to form stem-loop II structure (SLII) and hijack of translating 80S ribosome through the binding of SLIII to 40S subunit, which leads to efficient...

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PMID: 32574204
DOI: 10.1371/journal.ppat.1008308

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