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Article

Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.

Science (New York, N.Y.) - 2 Sept 2005

Jopling Catherine L, Yi Minkyung, Lancaster Alissa M, Lemon Stanley M, Sarnow Peter

Abstract excerpt

MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression. MicroRNA 122 (miR-122) is specifically expressed and highly abundant in the human liver. We show that the sequestration of miR-122 in liver cells results in marked loss of autonomously replicating hepatitis C viral RNAs. A genetic interaction between miR-122 and the 5' noncoding region of the viral genome was revealed by mutational...

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Identifiers

PMID: 16141076
DOI: 10.1126/science.1113329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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