Article
miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5' UTR RNA to stabilize and promote viral RNA accumulation.
Nucleic acids research - 12 Oct 2018
Amador-Cañizares Yalena, Panigrahi Mamata, Huys Adam, Kunden Rasika D, Adams Halim M, Schinold Michael J, Wilson Joyce A
Abstract excerpt
Annealing of the liver-specific microRNA, miR-122, to the Hepatitis C virus (HCV) 5' UTR is required for efficient virus replication. By using siRNAs to pressure escape mutations, 30 replication-competent HCV genomes having nucleotide changes in the conserved 5' untranslated region (UTR) were identified. In silico analysis predicted that miR-122 annealing induces canonical HCV genomic 5' UTR RNA folding, and...
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