Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3′ variants

22 Dec 2016

Abstract excerpt

In addition to suppressing cellular gene expression, certain miRNAs potently facilitate replication of specific positive-strand RNA viruses. miR-122, a pro-viral hepatitis C virus (HCV) host factor, binds and recruits Ago2 to tandem sites (S1 and S2) near the 5΄ end of the HCV genome, stabilizing it and promoting its synthesis. HCV target site selection follows canonical miRNA rules, but how non-templated 3΄...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to MicroRNA in disease regulation
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28082397
DOI: 10.1093/nar/gkw1332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3′ variantsPMID 28082397Read ↗

Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122Semantic proximity Read ↗

MicroRNA-122 Regulation of HCV Infections: Insights from Studies of miR-122-Independent ReplicationSemantic proximity Read ↗

Various miRNAs compensate the role of miR-122 on HCV replicationSemantic proximity Read ↗

Base Pairing between Hepatitis C Virus RNA and MicroRNA 122 3′ of Its Seed Sequence Is Essential for Genome Stabilization and Production of Infectious VirusSemantic proximity Read ↗

Hepatitis C virus' Achilles' heel--dependence on liver-specific microRNA miR-122.Semantic proximity Read ↗

miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure.Semantic proximity Read ↗

MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and TherapySemantic proximity Read ↗

Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitorsSemantic proximity Read ↗

Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.Semantic proximity Read ↗

Impact of a Patient-Derived Hepatitis C Viral RNA Genome with a Mutated MicroRNA Binding SiteSemantic proximity Read ↗

Human Ago2 Is Required for Efficient MicroRNA 122 Regulation of Hepatitis C Virus RNA Accumulation and TranslationSemantic proximity Read ↗

miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5' UTR RNA to stabilize and promote viral RNA accumulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.