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Article

miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2021

Chahal Jasmin, Gebert Luca F R, Camargo Carolina, MacRae Ian J, Sagan Selena M

Abstract excerpt

Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with a liver-specific microRNA called miR-122. miR-122 binds to two sites in the 5' untranslated region of the viral genome and promotes HCV RNA accumulation. This interaction is important for viral RNA accumulation in cell culture, and miR-122 inhibitors have been shown to be effective at reducing viral titers in chronic HCV-infected patients....

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Share to Antiviral Agents
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Gene Expression Regulation, Viral

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to MicroRNAs

Share to RNA, Viral

Source

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Identifiers

PMID: 34385308
DOI: 10.1073/pnas.2103671118
PMCID: PMC8379925

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