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Article

Positive Regulation of Hepatitis E Virus Replication by MicroRNA-122

15 Mar 2018

Abstract excerpt

ABSTRACT The molecular mechanisms of liver pathology and clinical disease in hepatitis E virus (HEV) infection remain unclear. MicroRNAs (miRNAs) are known to modulate viral pathogenesis either by directly altering viral gene expression or by enhancing cellular antiviral responses. Given the importance of microRNA-122 (miR-122) in liver pathobiology, we investigated possible role of miR-122 in HEV infection. In...

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PMID: 29540601
DOI: 10.1128/jvi.01999-17

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