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Article

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

28 Jun 2018

Abstract excerpt

The liver-specific microRNA-122 (miR-122) recognizes two conserved sites at the 5' end of the hepatitis C virus (HCV) genome and contributes to stability, translation, and replication of the viral RNA. We show that stimulation of the HCV internal ribosome entry site (IRES) by miR-122 is essential for efficient viral replication. The mechanism relies on a dual function of the 5' terminal sequence in the...

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PMID: 29973597
DOI: 10.1038/s41467-018-05053-3

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