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Article

Combination of IL-17 and TNFα induces a pro-inflammatory, pro-coagulant and pro-thrombotic phenotype in human endothelial cells.

Annals of the rheumatic diseases - 1 May 2012

Hot Arnaud, Lenief Vanina, Miossec Pierre

Abstract excerpt

OBJECTIVE: Cardiovascular events remain the leading cause of death in rheumatoid arthritis (RA). To study the role of cytokines in these observations, the effects of tumour necrosis factor α (TNFα) and interleukin (IL)-17, a classical and a new key player in RA, were assessed in endothelial cell (EC) dysfunction. METHODS: Primary human EC were treated with IL-17 alone or combined with TNFα. mRNA expression was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22258491
DOI: 10.1136/annrheumdis-2011-200468

Genes

CCL5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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