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Article

LIN28A‒let-7b axis drives the aggressive and proinflammatory phenotype of rheumatoid arthritis fibroblast-like synoviocytes.

Arthritis research & therapy - 13 Apr 2026

Chae Hee Young, Yi Kyungrim, Lim Su-Geun, Park Ji Yeong, Hyung Hyejin, Kim Si-Yong, Kim Wanil, Lee Sang-Il, Choi Dong Kyu, Kim Myoung Ok, Ryoo Zae Young, Ko Jiwon, Jang Soyeon

Abstract excerpt

BACKGROUND: Fibroblast-like synoviocytes (FLS) are central mediators of synovial inflammation and joint destruction in rheumatoid arthritis (RA). While tumor necrosis factor-α (TNFα) is known to activate FLS, the upstream regulators that connect inflammatory stimulation with sustained stromal pathogenicity remain poorly defined. The LIN28A‒let-7 microRNA axis regulates proliferation and invasiveness in diverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41975528
DOI: 10.1186/s13075-026-03809-7
PMCID: PMC13188475

Genes

LIN28A
HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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