Article
Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes.
Arthritis research & therapy - 28 Jul 2015
Varas Alberto, Valencia Jaris, Lavocat Fabien, Martínez Víctor G, Thiam Ndiémé Ndongo, Hidalgo Laura, Fernández-Sevilla Lidia M, Sacedón Rosa, Vicente Angeles, Miossec Pierre
Abstract excerpt
INTRODUCTION: Bone morphogenetic proteins (BMPs) are multifunctional secreted growth factors regulating a broad spectrum of functions in numerous systems. An increased expression and production of specific BMPs have been described in the rheumatoid arthritis (RA) synovium. The aim of this study was to analyze the involvement of the BMP signaling pathway in RA synoviocytes in response to interleukin-17 (IL-17) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.