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Article

Distribution of human CYP2C8*2 allele in three different African populations.

Malaria journal - 25 Apr 2012

Paganotti Giacomo M, Gramolelli Silvia, Tabacchi Francesca, Russo Gianluca, Modiano David, Coluzzi Mario, Romano Rita

Abstract excerpt

BACKGROUND: The aim of this study was to investigate cytochrome P450 2C8*2 (CYP2C8*2) distribution and allele frequency in three populations from West and East Africa exposed to Plasmodium falciparum malaria. CYP2C8 enzyme is involved in the metabolism of the anti-malarials amodiaquine and chloroquine. The presence of the CYP2C8*2 defective allele has been recently associated to higher rate of...

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Amodiaquine
Antimalarials
Aryl Hydrocarbon Hydroxylases
Chloroquine
Cytochrome P-450 CYP2C8

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PMID: 22531455
DOI: 10.1186/1475-2875-11-125
PMCID: PMC3353233

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