The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.

doi:10.1007/s10620-012-2171-y

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.

Digestive diseases and sciences - 1 Aug 2012

Clark Paul J, Thompson Alexander J, Zhu Qianqian, Vock David M, Zhu Mingfu, Patel Keyur, Harrison Stephen A, Naggie Susanna, Ge Dongliang, Tillmann Hans L, Urban Thomas J, Shianna Kevin, Fellay Jacques, Goodman Zachary, Noviello Stephanie, Pedicone Lisa D, Afdhal Nezam, Sulkowski Mark, Albrecht Janice K, Goldstein David B, McHutchison John G, Muir Andrew J

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms (SNPs) in the IL28B and PNPLA3 gene regions have been associated with hepatic steatosis in genotype 1 (G1) chronic HCV infection but their clinical impacts remain to be determined. AIM: We sought to validate these associations and to explore their impact on treatment response to peginterferon and ribavirin therapy. METHODS: A total of 972 G1 HCV-infected Caucasian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fatty Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Interferons

Share to Interleukins

Share to Lipase

Share to Membrane Proteins

Share to Prevalence

Share to Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 22543885
DOI: 10.1007/s10620-012-2171-y
PMCID: PMC3518927

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.PMID 22543885Read ↗

PNPLA3 rs738409 causes steatosis according to viral & IL28B genotypes in hepatitis C.Semantic proximity Read ↗

Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis.Semantic proximity Read ↗

Hepatic steatosis in chronic hepatitis C: baseline host and viral characteristics and influence on response to therapy with peginterferon alpha-2a plus ribavirin.Semantic proximity Read ↗

Impact of IL28B-related single nucleotide polymorphisms on liver histopathology in chronic hepatitis C genotype 2 and 3.Semantic proximity Read ↗

The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C.Semantic proximity Read ↗

Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C.Semantic proximity Read ↗

The influence of gene-chronic hepatitis C virus infection on hepatic fibrosis and steatosis.Semantic proximity Read ↗

Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C.Semantic proximity Read ↗

PNPLA3 rs1010023 Predisposes Chronic Hepatitis B to Hepatic Steatosis but Improves Insulin Resistance and Glucose Metabolism.Semantic proximity Read ↗

PNPLA3 rs738409 I748M is associated with steatohepatitis in 434 non-obese subjects with hepatitis C.Semantic proximity Read ↗

The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients.Semantic proximity Read ↗

PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.