Article
PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection.
BMC medical genetics - 14 Sept 2012
Rembeck Karolina, Maglio Cristina, Lagging Martin, Christensen Peer Brehm, Färkkilä Martti, Langeland Nina, Buhl Mads Rauning, Pedersen Court, Mørch Kristine, Norkrans Gunnar, Hellstrand Kristoffer, Lindh Magnus, Pirazzi Carlo, Burza Maria Antonella, Romeo Stefano, Westin Johan
Abstract excerpt
BACKGROUND: Hepatic steatosis in HCV patients has been postulated as a risk factor associated with a higher frequency of fibrosis and cirrhosis. A single genetic variant, PNPLA3 I148M, has been widely associated with increased hepatic steatosis. Previous studies of the PNPLA3 I148M sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis,...
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