Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative Polyadenylation and Nonsense-Mediated Decay Coordinately Regulate the Human HFE mRNA Levels

18 Apr 2012

Abstract excerpt

Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively recognizes and degrades defective mRNAs carrying premature translation-termination codons. However, several studies have shown that NMD also targets physiological transcripts that encode full-length proteins, modulating their expression. Indeed, some features of physiological mRNAs can render them NMD-sensitive. Human HFE is a MHC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Iron Metabolism and Disorders
Share to RNA Research and Splicing
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22530027
DOI: 10.1371/journal.pone.0035461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative Polyadenylation and Nonsense-Mediated Decay Coordinately Regulate the Human HFE mRNA LevelsPMID 22530027Read ↗

A novel homozygous stop-codon mutation in human HFE responsible for nonsense-mediated mRNA decay.Semantic proximity Read ↗

Transcriptome analysis of alternative splicing-coupled nonsense-mediated mRNA decay in human cells reveals broad regulatory potentialSemantic proximity Read ↗

Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses.Semantic proximity Read ↗

Transcriptome-wide analysis of primary human endothelial cell responses to 1 hour of protein translation inhibition identify nonsense mediated decay targets and a non-coding <i>SLC11A2</i> exon as an acute biomarkerSemantic proximity Read ↗

Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.Semantic proximity Read ↗

Posttranscriptional regulation of human ADH5/FDH and Myf6 gene expression by upstream AUG codons.Semantic proximity Read ↗

Nonsense Mutations in hERG Cause a Decrease in Mutant mRNA Transcripts by Nonsense-Mediated mRNA Decay in Human Long-QT SyndromeSemantic proximity Read ↗

Post-transcriptional control via iron-responsive elements: the impact of aberrations in hereditary disease.Semantic proximity Read ↗

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival.Semantic proximity Read ↗

Decay of the Stress-Induced Ligand MICA Is Controlled by the Expression of an Alternative 3' Untranslated Region.Semantic proximity Read ↗

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.Semantic proximity Read ↗

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.