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Article

Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses.

BMC cell biology - 24 Jul 2007

Lawless Matthew W, Mankan Arun K, White Mary, O'Dwyer Michael J, Norris Suzanne

Abstract excerpt

BACKGROUND: Hereditary Hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated allele are at risk for the development of a range of disorders particularly liver disease. Conformational diseases are a class of disorders associated with the expression of misfolded protein. HFE C282Y is a mutant protein that does not fold correctly...

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Source

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Identifiers

PMID: 17650303
DOI: 10.1186/1471-2121-8-30
PMCID: PMC1947972

Genes

HFE
ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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