Article
Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output.
Clinical and experimental pharmacology & physiology - 1 May 2012
Dulhunty Angela F, Wium Elize, Li Linwei, Hanna Amy D, Mirza Shamaruh, Talukder Sadik, Ghazali Nuur Aa, Beard Nicole A
Abstract excerpt
SUMMARY: The contractile function of the heart requires the release of Ca(2+) from intracellular Ca(2+) stores in the sarcoplasmic reticulum (SR) of cardiac muscle cells. The efficacy of Ca(2+) release depends on the amount of Ca(2+) loaded into the Ca(2+) store and the way in which this 'Ca(2+) load' influences the activity of the cardiac ryanodine receptor Ca(2+) release channel (RyR2). The effects of...
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