Article
Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis.
Circulation research - 1 Apr 2011
Priori Silvia G, Chen S R Wayne
Abstract excerpt
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is characterized by life-threatening arrhythmias elicited by stress and emotion. In 2001, the ryanodine receptor was identified as the gene that is linked to CPVT; shortly thereafter, cardiac calsequestrin was implicated in the recessive form of...
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