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Article

Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia.

The Journal of physiology - 1 Jul 2020

Wleklinski Matthew J, Kannankeril Prince J, Knollmann Bjӧrn C

Abstract excerpt

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-induced cardiac channelopathy that has a high mortality in untreated patients. Our understanding has grown tremendously since CPVT was first described as a clinical syndrome in 1995. It is now established that the deadly arrhythmias are caused by unregulated 'pathological' calcium release from the sarcoplasmic reticulum (SR), the major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32115705
DOI: 10.1113/JP276757
PMCID: PMC7699301

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