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Article

RYR2-ryanodinopathies: from calcium overload to calcium deficiency.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 2 Jun 2023

Steinberg Christian, Roston Thomas M, van der Werf Christian, Sanatani Shubhayan, Chen S R Wayne, Wilde Arthur A M, Krahn Andrew D

Abstract excerpt

The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel RyR2 is an essential regulator of cardiac excitation-contraction coupling and intracellular calcium homeostasis. Mutations of the RYR2 are the cause of rare, potentially lethal inherited arrhythmia disorders. Catecholaminergic polymorphic ventricular tachycardia (CPVT) was first described more than 20 years ago and is the most...

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Identifiers

PMID: 37387319
DOI: 10.1093/europace/euad156
PMCID: PMC10311407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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