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Article

Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditions.

The Journal of general physiology - 1 Aug 2013

Chen Haiyan, Valle Giorgia, Furlan Sandra, Nani Alma, Gyorke Sandor, Fill Michael, Volpe Pompeo

Abstract excerpt

Release of Ca(2+) from the sarcoplasmic reticulum (SR) drives contractile function of cardiac myocytes. Luminal Ca(2+) regulation of SR Ca(2+) release is fundamental not only in physiology but also in physiopathology because abnormal luminal Ca(2+) regulation is known to lead to arrhythmias, catecholaminergic polymorphic ventricular tachycardia (CPVT), and/or sudden cardiac arrest, as inferred from animal model...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23858002
DOI: 10.1085/jgp.201311022
PMCID: PMC3727306

Genes

CASQ2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditions.PMID 23858002Read ↗

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