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Article

Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production.

Applied and environmental microbiology - 1 Jul 2012

Cartman Stephen T, Kelly Michelle L, Heeg Daniela, Heap John T, Minton Nigel P

Abstract excerpt

Clostridium difficile causes a potentially fatal diarrheal disease through the production of its principal virulence factors, toxin A and toxin B. The tcdC gene is thought to encode a negative regulator of toxin production. Therefore, increased toxin production, and hence increased virulence, is often inferred in strains with an aberrant tcdC genotype. This report describes the first allele exchange system for...

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Identifiers

PMID: 22522680
DOI: 10.1128/AEM.00249-12
PMCID: PMC3370502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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