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Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile

27 Nov 2020

Abstract excerpt

Toxin-antitoxin (TA) systems are widespread on mobile genetic elements and in bacterial chromosomes. In type I TA, synthesis of the toxin protein is prevented by the transcription of an antitoxin RNA. The first type I TA were recently identified in the human enteropathogen Clostridioides difficile. Here we report the characterization of five additional type I TA within phiCD630-1 (CD0977.1-RCd11, CD0904.1-RCd13...

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PMID: 33247281
DOI: 10.1038/s42003-020-01448-5

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