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Article

Toxin gene analysis of a variant strain of Clostridium difficile that causes human clinical disease.

Infection and immunity - 1 Oct 2000

Sambol S P, Merrigan M M, Lyerly D, Gerding D N, Johnson S

Abstract excerpt

A toxin variant strain of Clostridium difficile was isolated from two patients with C. difficile-associated disease (CDAD), one of whom died from extensive pseudomembranous colitis. This strain, identified by restriction endonuclease analysis (REA) as type CF2, was not detected by an immunoassay for C. difficile toxin A. Culture supernatants of CF2 failed to elicit significant enterotoxic activity in the rabbit...

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Source

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Identifiers

PMID: 10992443
DOI: 10.1128/IAI.68.10.5480-5487.2000
PMCID: PMC101495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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