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Axonal Transport Defects in Neurodegenerative Diseases

14 Oct 2009

Abstract excerpt

Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of neurological disorders characterized by a progressive, age-dependent decline in neuronal function and loss of selected neuronal populations. Alterations in synaptic function and axonal connectivity represent early and critical pathogenic events in AONDs, but molecular mechanisms underlying these defects remain elusive. The large size...

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PMID: 19828789
DOI: 10.1523/jneurosci.3463-09.2009

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