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Article

Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Apr 2012

Srivastava Taasin, Fortin Dale A, Nygaard Sean, Kaech Stefanie, Sonenberg Nahum, Edelman Arthur M, Soderling Thomas R

Abstract excerpt

Ca²⁺/calmodulin-dependent kinases (CaMKs) are essential for neuronal development and plasticity, processes requiring de novo protein synthesis. Roles for CaMKs in modulating gene transcription are well established, but their involvement in mRNA translation is evolving. Here we report that activity-dependent translational initiation in cultured rat hippocampal neurons is enhanced by CaMKI-mediated phosphorylation...

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Identifiers

PMID: 22514323
DOI: 10.1523/JNEUROSCI.0030-12.2012
PMCID: PMC3346851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII.PMID 22514323Read ↗

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