Article

Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators

2024-02-07

Abstract excerpt

<h4>SUMMARY</h4> Neuronal activity stimulates mRNA translation crucial for learning and development. While FMRP (Fragile X Mental Retardation Protein) and CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1) regulate translation, the mechanism linking translation to neuronal activity is not understood. We now find that translation is stimulated when FMRP and CYFIP1 translocate to the potassium channel Slack (KCNT1, Sl...

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Literature Corpus work: b774b9d9-5916-5b97-9926-692bcb6fbf33
DOI: 10.1101/2024.02.07.579306

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