Article

Mechanisms of USP7/MAGEL2 Complex Assembly and Its Mutational Disruption in Neurodevelopmental Diseases

2026-04-28

Abstract excerpt

<h4>ABSTRACT</h4> The WASH complex regulates endosomal trafficking and is linked to several neurodevelopmental diseases, including Prader-Willi syndrome, Schaaf-Yang syndrome, and Hao-Fountain syndrome. Its function is tightly controlled by ubiquitination, maintained by the multi-subunit MUST complex containing both a ubiquitin ligase (MAGEL2/TRIM27) and a deubiquitinase (USP7). However, the mechanism underlying...

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Literature Corpus work: 66518ec7-f556-565e-a16a-2e9d49f15103
DOI: 10.64898/2026.04.24.720667

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