Article
Interleukin-4 genetic variants correlate with its transcript and protein levels in patients with vitiligo.
The British journal of dermatology - 1 Aug 2012
Imran M, Laddha N C, Dwivedi M, Mansuri M S, Singh J, Rani R, Gokhale R S, Sharma V K, Marfatia Y S, Begum R
Abstract excerpt
BACKGROUND: Vitiligo is an acquired pigmentary disorder resulting from loss of melanocytes. Interleukin (IL)-4 has been shown to stimulate B-cell proliferation, to regulate immunoglobulin class switching (IgG1 and IgE) and to promote T-cell development. Polymorphisms in the IL4 gene are known to increase its expression, thereby implicating its role in vitiligo susceptibility. OBJECTIVES: To explore intron 3 VNTR...
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