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Investigation of the Role of Interleukin 6 in Vitiligo Pathogenesis.

Immunological investigations - 1 Jan 2022

Singh Mala, Jadeja Shahnawaz D, Vaishnav Jayvadan, Mansuri Mohmmad Shoab, Shah Chandni, Mayatra Jay M, Shah Atul, Begum Rasheedunnisa

Abstract excerpt

Interleukin-6 (IL6) is involved in pathogenesis of several autoimmune disorders including vitiligo. Hence, we aimed to investigate the association of IL6 -174 G/C and -572 G/C polymorphisms and its transcript levels with vitiligo; to evaluate the effect of IL-6 on normal human melanocyte (NHM) viability and expression of IL6R, MITF and TYR. IL6 -174 G/C and -572 G/C polymorphisms were genotyped by ARMS-PCR and...

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PMID: 32865069
DOI: 10.1080/08820139.2020.1813756

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